Frontmatter

Publicly Available i
About the Editors

Publicly Available v
Historical Development and Perspectives of the Series Metal Ions in Life Sciences

Publicly Available vii
Preface to Volume 22 Metal Ions in Bio-Imaging Techniques

Publicly Available ix
Contents

Publicly Available xiii
Contributors to Volume 22

Publicly Available xix
Titles of Volumes 1–44 in the Metal Ions in Biological Systems Series

Publicly Available xxiii
Contents of Volumes in the Metal Ions in Life Sciences Series

Publicly Available xxv
1 Metal Ions in Bio-Imaging Techniques: A Short Overview

Sergey Shuvaev and Peter Caravan
Licensed 1
2 Gadolinium(III)-Based Contrast Agents for Magnetic Resonance Imaging. A Re-Appraisal

Gyula Tircsó, Enikő Molnár, Tibor Csupász, Zoltán Garda, Richárd Botár, Ferenc K. Kálmán, Zoltán Kovács, Ernő Brücher and Imre Tóth
Licensed 39
3 Manganese Complexes as Contrast Agents for Magnetic Resonance Imaging

Sara Lacerda, Daouda Ndiaye and Éva Tóth
Licensed 71
4 Metal Ion Complexes in Paramagnetic Chemical Exchange Saturation Transfer (ParaCEST)

Aurora Rodríguez-Rodríguez, Moritz Zaiss, David Esteban-Gómez, Goran Angelovski and Carlos Platas-Iglesias
Licensed 101
5 Lanthanide Complexes Used for Optical Imaging

Thomas Just Sørensen and Stephen Faulkner
Licensed 137
6 Radiometals for Positron Emission Tomography (PET) Imaging

Shin Hye Ahn, Alexia G. Cosby, Angus J. Koller, Kirsten E. Martin, Apurva Pandey, Brett A. Vaughn and Eszter Boros
Licensed 157
7 99mTechnetium-Based Imaging Agents and Developments in 99Tc Chemistry

Roger Alberto and Qaisar Nadeem
Licensed 195
8 Paramagnetic Metal Ion Probes for 19F Magnetic Resonance Imaging

Petr Hermann, Jan Blahut, Jan Kotek and Vít Herynek
Licensed 239
9 Iron Oxide Nanoparticles for Bio-Imaging

Carlos F. G. C. Geraldes and Marie Hélène Delville
Licensed 271
10 Magnetic Resonance Contrast Enhancement and Therapeutic Properties of Corrole Nanoparticles

James Teh and Lali Medina Kauwe
Licensed 299
11 Positron Emission Tomography (PET) Driven Theranostics

Suresh Pandey, Giovanni Battista Giovenzana, Dezsö Szikra and Zsolt Baranyai
Licensed 315
12 Magnetic Resonance Theranostics: An Overview of Gadolinium(III)-Based Strategies and Magnetic Particle Imaging

Shaunna M. McLeod and Thomas J. Meade
Licensed 347
13 Luminescence Imaging of Cancer Cells

Jorge H. S. K. Monteiro, Josiane A. Sobrinho and Ana de Bettencourt-Dias
Licensed 371
14 Iridium(III) Complexes in Bio-Imaging Including Mitochondria

Cai-Ping Tan, Jie Wang, Liang-Nian Ji and Zong-Wan Mao
Licensed 403
15 Imaging Bacteria with Contrast-Enhanced Magnetic Resonance

Casey J. Adams and Thomas J. Meade
Licensed 425
16 Transition Metals and Imaging Probes in Neurobiology and Neurodegenerative Diseases

Ho Yu Au-Yeung and Ka Yan Tong
Licensed 437
17 Heavy Elements for X-Ray Contrast

Yuxi C. Dong and David P. Cormode
Licensed 457
Subject Index

Licensed 485
(Deutsch)

Volume 22, entitled Metal Ions in Bio-Imaging Techniques, of the series Metal Ions in Life Sciences deals with metal ions as tools in imaging. This dates back to the first half of the past century, when barium sulfate was orally given to patients undergoing X-ray examination. The use of contrast agents has since developed into a large interdisciplinary field encompassing not only medicine, but also chemistry, material sciences, physics, biology, engineering, and computer sciences. MILS-22 provides deep and current insights in 17 stimulating chapters on the new research frontiers of this fast growing field on bio-imaging ... and beyond. For example, adding bio-sensing yields theranostic agents, meaning diagnosis and therapy linked in the same molecule; ions of Gd, Mn, Fe, Co, Ir, 99mTc, etc., are involved. Other important topics are, e.g., metal complexes in paramagnetic Chemical Exchange Transfer (paraCEST), radiometals for Positron Emission Tomography (PET) imaging, or paramagnetic metal ion probes for 19F magnetic resonance imaging. MILS-22 is written by 57 internationally recognized experts from 12 countries, that is, from the US via Europe to China. The impact of this vibrant research area is manifested by more than 2300 references and nearly 120 figures, mostly in color, and several informative tables. To conclude, Metal Ions in Bio-Imaging Techniques is an essential resource for scientists working in the wide range from material sciences, enzymology, analytic, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that also excellent information for teaching is provided.

• It reveals the interplay between imaging and diagnosis
• It provides an understanding of the demands in the clinic
• It provides insights into theranostics